NEDD4-2 Rabbit Monoclonal Antibody (CAB9078)
- SKU:
- CAB9078
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- NEDD4-2
- NEDD4.2
- PVNH7
- RSP5
- hNEDD4-2
- Research Area:
- Developmental Biology
Frequently bought together:
Description
Product Name: | NEDD4-2 Rabbit Monoclonal Antibody |
SKU: | CAB9078 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 876-975 of human NEDD4L (Q96PU5). |
Sequence: | NHPV IQWF WKAV LLMD AEKR IRLL QFVT GTSR VPMN GFAE LYGS NGPQ LFTI EQWG SPEK LPRA HTCF NRLD LPPY ETFE DLRE KLLM AVEN AQGF EGVD |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | RSP5; PVNH7; NEDD4-2; NEDD4.2; hNEDD4-2; NEDD4L |
Positive Sample: | HeLa,K-562 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, cytosol, extracellular exosome, Golgi apparatus, multivesicular body, nucleoplasm |
Calculated MW: | 112kDa |
Observed MW: | 135kDa |
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method: | Affinity purification |
Gene ID: | 23327 |
Clone Number: | ARC1404 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |