The Anti-Nectin4 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0276) is a cutting-edge tool for researchers studying Nectin4, a cell adhesion molecule involved in cell-cell interactions and signaling pathways. This antibody, produced through recombinant technology in rabbits, exhibits high specificity and sensitivity towards Nectin4 in human samples, making it suitable for a variety of applications, including immunohistochemistry and flow cytometry.Nectin4, also known as PVRL4, is known to play a crucial role in various physiological processes, including cell adhesion, migration, and proliferation. Its overexpression has been associated with tumorigenesis and metastasis in multiple cancer types, making it a potential therapeutic target for cancer treatment.
By utilizing the Anti-Nectin4 Chimeric Recombinant Rabbit Monoclonal Antibody, researchers can investigate the role of Nectin4 in cancer progression and explore its potential as a biomarker for cancer diagnosis and prognosis.Whether studying the molecular mechanisms underlying Nectin4-mediated signaling pathways or evaluating its expression in cancer tissues, this antibody provides an indispensable tool for advancing research in oncology and cell biology. Its high affinity and specificity make it a reliable reagent for exploring the functions and therapeutic potential of Nectin4 in various disease contexts.
SKU:
HDAB0276
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC438
Synonyms:
EDSS1, LNIR, nectin-4, PRR4, PVRL4
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
