The N4BP2 Polyclonal Antibody (CAB20480) is a valuable tool for researchers studying N4BP2, a key protein involved in various cellular processes. This antibody, produced in rabbits, specifically targets N4BP2 and is highly reactive with human samples. Validated for use in Western blot applications, the antibody enables the detection and analysis of N4BP2 expression in a variety of cell types.N4BP2, also known as Nedd4 binding protein 2, is a multifunctional protein that plays a critical role in regulating cell growth, apoptosis, and signal transduction pathways. Its dysregulation has been implicated in diseases such as cancer, neurodegenerative disorders, and metabolic conditions.
Studying the function of N4BP2 is essential for gaining insight into these diseases and developing targeted therapies.With its high specificity and sensitivity, the N4BP2 Polyclonal Antibody is a valuable tool for researchers in the fields of cell biology, cancer research, and more. By enabling accurate detection and analysis of N4BP2 protein levels, this antibody facilitates in-depth studies into the role of N4BP2 in various physiological and pathological processes.
Product Name:
N4BP2 Rabbit Polyclonal Antibody
SKU:
CAB20480
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 190-320 of human N4BP2 (NP_060647.2).
This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
55728
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat large intestine, using N4BP2 antibody (CAB20480) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
