The MVK Polyclonal Antibody (CAB20906) is a valuable tool for researchers studying mevalonate kinase (MVK), an enzyme involved in the biosynthesis of cholesterol and other isoprenoids. This antibody, raised in rabbits, offers high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to MVK, this antibody enables researchers to detect and analyze the protein in various cell types, making it ideal for studies in lipid metabolism and related disorders.MVK plays a crucial role in the mevalonate pathway, which is essential for the production of cholesterol, steroid hormones, and other important molecules in the body.
Dysregulation of this pathway has been implicated in various diseases, including metabolic disorders and certain types of cancer. By studying MVK and its regulation, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.With its specificity and reliability, the MVK Polyclonal Antibody (CAB20906) offers a valuable tool for investigating the role of MVK in health and disease. Whether studying lipid metabolism, cholesterol biosynthesis, or related pathways, this antibody can provide essential support for your research endeavors.
Product Name:
MVK Monoclonal Antibody
SKU:
CAB20906
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 297-396 of human MVK (Q03426).
This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4598
Clone Number:
ARC2871
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of HepG2 cells, using MVK antibody (CAB20906) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
