The Anti-Musashi-1 (MSI1) Antibody (CAB9122) is a critical tool for research involving the Musashi-1 protein, a key regulator of stem cell function and neural development. This antibody, produced in rabbits, is highly specific for detecting Musashi-1 in human samples and has been validated for use in Western blot and immunohistochemistry applications. By binding to Musashi-1, this antibody enables researchers to investigate the expression and localization of this important protein in various tissues and cell types.Musashi-1 is known for its role in promoting self-renewal and maintaining the pluripotency of stem cells, making it a crucial target for studies in stem cell biology and regenerative medicine.
Additionally, Musashi-1 has been implicated in various cancers, including glioblastoma and colorectal cancer, where its overexpression is associated with tumor aggressiveness and poor prognosis. The Anti-Musashi-1 (MSI1) Antibody is therefore an invaluable tool for investigating the function of Musashi-1 in both normal and disease contexts, offering insights into potential therapeutic strategies for targeting this protein in cancer treatment.
Product Name:
Musashi-1 (MSI1) Rabbit Monoclonal Antibody
SKU:
CAB9122
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MSI1 (O43347).
MSI1; musashi RNA binding protein 1; Musashi-1 (MSI1)
Positive Sample:
SH-SY5Y,Mouse brain
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
39kDa
Observed MW:
39kDa
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13.
Purification Method:
Affinity purification
Gene ID:
4440
Clone Number:
ARC1796
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Musashi-1 (MSI1) Rabbit mAb (CAB9122) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
