The Anti-MUC4 Antibody (CAB3438) is a valuable tool for researchers studying MUC4, a glycoprotein involved in cell adhesion and signaling. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in multiple applications, including immunohistochemistry and Western blotting. By binding specifically to the MUC4 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in cancer biology and mucin research.MUC4, a membrane-bound mucin, is known for its role in promoting tumor progression and metastasis in various cancers.
Its aberrant expression has been linked to poor prognosis in patients, making it a promising target for therapeutic intervention. Research into MUC4 function is critical for understanding its impact on cancer development and progression, as well as for identifying potential therapeutic strategies to target this molecule in cancer treatment. The Anti-MUC4 Antibody (CAB3438) provides researchers with a reliable tool to investigate the biological functions of MUC4 and its implications in cancer biology.
Product Name:
MUC4 Rabbit Monoclonal Antibody
SKU:
CAB3438
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 4807-4916 of human MUC4 (Q99102).
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats.
Purification Method:
Affinity purification
Gene ID:
4585
Clone Number:
ARC1999
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using MUC4 Rabbit mAb (CAB3438) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 10s.
