The MRPS31 Polyclonal Antibody (CAB20932) is a valuable tool for researchers studying mitochondrial ribosomal protein S31 (MRPS31), a key component in mitochondrial protein synthesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the MRPS31 protein, it allows for accurate detection and analysis in various cell types, making it an essential asset for studies in molecular biology and mitochondrial research.MRPS31 is essential for the correct assembly and function of the mitochondrial ribosome, which is responsible for synthesizing proteins needed for mitochondrial function.
Dysregulation of MRPS31 has been linked to mitochondrial dysfunction and various diseases, including metabolic disorders and neurodegenerative conditions. Investigating the role of MRPS31 can provide valuable insights into these pathological processes and potential therapeutic targets for treating associated disorders.Overall, the MRPS31 Polyclonal Antibody is a reliable tool for researchers interested in understanding the molecular mechanisms underlying mitochondrial protein synthesis and its implications for human health. Its specificity and sensitivity make it an indispensable resource for studies exploring the role of MRPS31 in mitochondrial function and associated diseases.
Product Name:
MRPS31 Monoclonal Antibody
SKU:
CAB20932
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 296-395 of human MRPS31 (Q92665).
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13.
Purification Method:
Affinity purification
Gene ID:
10240
Clone Number:
ARC2914
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MRPS31 antibody (CAB20932) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
