The Anti-MRP1/ABCC1 Antibody (CAB2223) is a valuable tool for researchers studying multidrug resistance protein 1 (MRP1), also known as ATP-binding cassette sub-family C member 1 (ABCC1). This antibody, raised in rabbits, is highly specific and reacts well with human samples in Western blot applications.MRP1/ABCC1 is a membrane protein that plays a key role in mediating drug resistance in cancer cells by actively pumping chemotherapeutic drugs out of the cells, thus reducing their effectiveness.
Understanding the mechanism of MRP1/ABCC1 can lead to the development of strategies to overcome drug resistance in cancer treatment.This antibody enables the detection and analysis of MRP1/ABCC1 in various cell types, making it a valuable tool for research in cancer biology and drug resistance mechanisms. By studying the expression and function of MRP1/ABCC1, researchers can develop targeted therapies to improve cancer treatment outcomes.
Product Name:
MRP1 Rabbit Monoclonal Antibody
SKU:
CAB2223
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 210-304 of human MRP1/ABCC1 (NP_004987.2).
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.
Purification Method:
Affinity purification
Gene ID:
4363
Clone Number:
ARC52207
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from A-549 cells, using MRP1/ABCC1 Rabbit mAb (CAB2223) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1S.
