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Anti-MRAP Antibody (CAB20597)

SKU:
CAB20597
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
B27
FALP
FGD2
GCCD2
C21orf61
€359
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Description

Product Name:MRAP Rabbit pAb
Product Code:CAB20597
Size:50uL, 100uL
Synonyms:B27, FALP, FGD2, GCCD2, C21orf61
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MRAP (NP_848932.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MRAP (NP_848932.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:56246
Uniprot:Q8TCY5
Calculated MW:19kDa
Observed MW:Refer to figures
UniProt Protein Function:MRAP: Required for MC2R expression in certain cell types, suggesting that it is involved in the processing, trafficking or function of MC2R. May be involved in the intracellular trafficking pathways in adipocyte cells. Defects in MRAP are the cause of glucocorticoid deficiency type 2 (GCCD2); also known as familial glucocorticoid deficiency type 2 (FGD2). GCCD2 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral Chromosomal Location of Human Ortholog: 21q22.1 Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; plasma membrane; integral to membrane Molecular Function: type 5 melanocortin receptor binding; type 3 melanocortin receptor binding; protein binding; type 4 melanocortin receptor binding; adrenocorticotropin hormone receptor binding Biological Process: positive regulation of cAMP biosynthetic process; brown fat cell differentiation Disease: Glucocorticoid Deficiency 2
UniProt Protein Details:
NCBI Summary:This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]
UniProt Code:Q8TCY5
NCBI GenInfo Identifier:45827704
NCBI Gene ID:56246
NCBI Accession:NP_996781.1
UniProt Secondary Accession:Q8TCY5,Q5EBR3, Q8TDB7, Q8WXC1, Q8WXC2
UniProt Related Accession:Q8TCY5
Molecular Weight:19,136 Da
NCBI Full Name:melanocortin-2 receptor accessory protein isoform beta
NCBI Synonym Full Names:melanocortin 2 receptor accessory protein
NCBI Official Symbol:MRAP  
NCBI Official Synonym Symbols:B27; FALP; FGD2; GCCD2; C21orf61  
NCBI Protein Information:melanocortin-2 receptor accessory protein; fat tissue-specific low MW protein; fat cell-specific low molecular weight protein
UniProt Protein Name:Melanocortin-2 receptor accessory protein
UniProt Synonym Protein Names:B27; Fat cell-specific low molecular weight protein; Fat tissue-specific low MW protein
Protein Family:Melanocortin-2 receptor accessory protein
UniProt Gene Name:MRAP  
UniProt Entry Name:MRAP_HUMAN

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