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Anti-Mouse PD-1 Antibody [RMP1-14] In Vivo - Low Endotoxin

SKU:
IVMB0037
Product Type:
In Vivo Monoclonal Antibody
Clone:
RMP1-14
Protein:
PD-1
Isotype:
Rat IgG2a kappa
Reactivity:
Mouse
Synonyms:
Programmed Death-1
CD279
PD 1
Research Area:
Immune Checkpoint & Cancer Biology
Endotoxin Level:
Low Endotoxin
Host Species:
Rat
Applications:
Blocking
FA
WB
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€125 - €3,381
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Description

system_update_altTechnical Datasheet

Anti-Mouse PD-1 Antibody [RMP1-14] In Vivo - Low Endotoxin

Introducing the Anti-Mouse PD-1 [RMP1-14] In Vivo Antibody - Low Endotoxin from Assay Genie, a highly specific monoclonal antibody designed for in vivo applications. This antibody targets the programmed cell death protein 1 (PD-1), a key regulator of immune response, making it ideal for research in immunology and related fields. With a rat IgG2a isotype, it ensures high purity and low endotoxin levels (<1.0 EU/mg), perfect for ELISA, flow cytometry, immunohistochemistry, and other assays.

Available in various sizes, it is formulated in phosphate-buffered saline for stability and efficacy. Enhance your research with this reliable and versatile antibody. PD-1 is a protein found on the surface of T-cells and pro-B cells. It plays a significant role in the immune system by inhibiting T-cell activity to prevent autoimmune responses. This makes it a crucial target in cancer immunotherapy and autoimmune disease research.

Product Name:Anti-Mouse PD-1 (CD279) [RMP1-14] In Vivo Antibody - Low Endotoxin
Product Code:IVMB0037
Size:1mg, 5mg, 25mg, 50mg, 100mg
Clone:RMP1-14
Protein:PD-1
Product Type:Monoclonal Antibody
Synonyms:Programmed Death-1, CD279, PD 1
Isotype:Rat IgG2a κ
Reactivity:Mouse
Immunogen:Mouse PD-1 transfected BHK cells
Applications:B, FA, WB
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Purity:≥95% monomer by analytical SEC
>95% by SDS Page
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Product CodeProduct NameEndotoxin Level
IVMB0037Anti-Mouse PD-1 (CD279) [RMP1-14] In Vivo Antibody - Low EndotoxinLow
IVMB0038Anti-Mouse PD-1 (CD279) [RMP1-14] In Vivo Antibody - Ultra Low EndotoxinUltra Low
Applications:B, FA, WB
Reactivity:Mouse
Host Species:Rat
Specificity:Clone RMP1-14 recognizes an epitope on mouse PD-1.
Antigen Distribution:PD-1 is expressed on a subset of CD4-CD8- thymocytes, and on activated T and B cells.
Immunogen:Mouse PD-1 transfected BHK cells
Concentration:≥ 5.0 mg/ml
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Purity:≥95% monomer by analytical SEC
>95% by SDS Page
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

PD-1 is a 50-55 kD member of the B7 Ig superfamily. PD-1 is also a member of the extended CD28/CTLA-4 family of T cell regulators and is suspected to play a role in lymphocyte clonal selection and peripheral tolerance. The ligands of PD-1 are PD-L1 and PD-L2, and are also members of the B7 Ig superfamily. PD-1 and its ligands negatively regulate immune responses. PD-L1, or B7-Homolog 1, is a 40 kD type I transmembrane protein that has been reported to costimulate T cell growth and cytokine production. The interaction of PD-1 with its ligand PD-L1 is critical in the inhibition of T cell responses that include T cell proliferation and cytokine production. PD-L1 has increased expression in several cancers. Inhibition of the interaction between PD-1 and PD-L1 can serve as an immune checkpoint blockade by improving T-cell responses In vitro and mediating preclinical antitumor activity. Within the field of checkpoint inhibition, combination therapy using anti-PD1 in conjunction with anti-CTLA4 has significant therapeutic potential for tumor treatments. PD-L2 is a 25 kD type I transmembrane ligand of PD-1. Via PD-1, PD-L2 can serve as a co-inhibitor of T cell functions. Regulation of T cell responses, including enhanced T cell proliferation and cytokine production, can result from mAbs that block the PD-L2 and PD-1 interaction.

Technical Datasheet:View
Protein:PD-1
Function:Lymphocyte clonal selection, peripheral tolerance
Ligand/Receptor:PD-L1 (B7-H1), PD-L2
Research Area:Apoptosis, Cancer, Cell Biology, Cell Death, Immunology, Inhibitory Molecules, Tumor Suppressors
Turley et al.Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8+ T cell-dependent anti-tumor immunityCell Reports Medicine 2024PubMed ID: 38729159
Product Thumbnail
Rat IgG2a Isotype Control
Clone 1-1
Isotype Rat IgG2a
Endotoxin Level Low Endotoxin
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