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Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Ultra Low Endotoxin (IVMB0073)

SKU:
IVMB0073
Product Type:
In Vivo Monoclonal Antibody
Clone:
9D9
Protein:
CTLA-4
Isotype:
Mouse IgG2b
Reactivity:
Mouse
Synonyms:
CD152
Cytotoxic T Lymphocyte-Associated Antigen-4
Ly-56
Research Area:
Immune Checkpoint & Cancer Biology
Endotoxin Level:
Ultra Low Endotoxin
Host Species:
Mouse
Applications:
FA
WB
€359 - €4,859
Frequently bought together:

Description

system_update_altTechnical Datasheet

Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Ultra Low Endotoxin

Introducing the Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Ultra Low Endotoxin from Assay Genie, a specialized monoclonal antibody tailored for in vivo research. This antibody specifically targets the CTLA-4 protein, a critical regulator in immune checkpoint pathways, making it indispensable for studies in immunology, particularly those investigating immune response modulation and autoimmunity. With a rat IgG2b kappa isotype, this antibody ensures exceptional purity and ultra-low endotoxin levels (<0.001 EU/µg), making it ideal for sensitive applications such as ELISA, flow cytometry, functional assays, and in vivo experiments. Available in multiple sizes, it is formulated in a phosphate-buffered saline solution to maintain its stability and efficacy under experimental conditions.

Enhance the precision and reliability of your immunological research with the Anti-Mouse CTLA-4 [9D9] In Vivo Antibody from Assay Genie. CTLA-4 (Cytotoxic T-Lymphocyte-associated Protein 4) is a protein receptor that downregulates immune responses. CTLA-4 is predominantly expressed on the surface of T cells and plays a pivotal role in managing immune homeostasis and preventing autoimmune reactions. By targeting CTLA-4, researchers can explore novel therapeutic avenues in cancer immunotherapy and autoimmune disease management.

Product Name:Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Ultra Low Endotoxin
Product Code:IVMB0073
Size:1mg, 5mg, 25mg, 50mg, 100mg
Clone:9D9
Protein:CTLA-4
Product Type:Monoclonal Antibody
Synonyms:CD152, Cytotoxic T Lymphocyte-Associated Antigen-4, Ly-56
Isotype:Mouse IgG2b
Reactivity:Mouse
Immunogen:Not Available
Applications:FA, WB
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Endotoxin Level:<0.5 EU/mg as determined by the LAL method
Purity:≥98% monomer by analytical SEC
>95% by SDS Page
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Product CodeProduct NameEndotoxin Level
IVMB0072Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Low EndotoxinLow
IVMB0073Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Ultra Low EndotoxinUltra Low
Applications:FA, WB
Reactivity:Mouse
Host Species:Mouse
Specificity:Clone 9D9 recognizes an epitope on mouse CTLA-4.
Antigen Distribution:CTLA-4 is expressed on activated T and B lymphocytes.
Immunogen:Not Available
Concentration:≥ 5.0 mg/ml
Endotoxin Level:<0.5 EU/mg as determined by the LAL method
Purity:≥98% monomer by analytical SEC
>95% by SDS Page
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity.

Technical Datasheet:View
Protein:CTLA-4
Function:Negative regulator of T cell activation
Ligand/Receptor:CD80 (B7.1), CD86 (B7.2)
Research Area:Immunology, Inhibitory Molecules
Product Thumbnail
Mouse IgG2b Isotype Control
Clone MPC-11
Isotype Mouse IgG2b
Endotoxin Level Ultra Low Endotoxin
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