MICA Rabbit Monoclonal Antibody (CAB19256)
- SKU:
- CAB19256
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MICA
- MIC-A
- PERB11.1
- MHC class I polypeptide-related sequence A
Description
Product Name: | MICA Rabbit Monoclonal Antibody |
SKU: | CAB19256 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MICA (Q29983). |
Sequence: | HLDG QPFL RCDR QKCR AKPQ GQWA EDVL GNKT WDRE TRDL TGNG KDLR MTLA HIKD QKEG LHSL QEIR VCEI HEDN STRS SQHF YYDG ELFL SQNL ETKE W |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | MIC-A; PERB11.1; MICA |
Positive Sample: | MCF7,Jurkat,OVCAR3,Mouse stomach,Rat stomach |
Conjugate: | Unmodified |
Cellular Localization: | Cell membrane, Cytoplasm, Single-pass type I membrane protein. |
Calculated MW: | 43kDa |
Observed MW: | 43kDa/60-80kDa |
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 100507436 |
Clone Number: | ARC2422 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |