The Anti-MICA Antibody (CAB19256) is a valuable tool for researchers studying the MICA protein, which plays a key role in immune responses and is involved in the recognition of abnormal cells by the immune system. This polyclonal antibody, produced in rabbits, is highly specific to human samples and is validated for use in various applications, including Western blotting.MICA, a stress-induced protein, serves as a ligand for the NKG2D receptor on natural killer cells and CD8+ T cells, triggering the immune response against infected or transformed cells.
By targeting MICA, researchers can gain insights into immune surveillance mechanisms and potentially develop new strategies for cancer immunotherapy.The Anti-MICA Antibody is a valuable tool for investigating the role of MICA in immune evasion and tumor immune escape, making it a crucial component in studies focused on cancer, autoimmune diseases, and transplantation. Researchers can utilize this antibody to detect and analyze MICA expression in various cell types, advancing our understanding of immune regulation and potential therapeutic targets.
Product Name:
MICA Rabbit Monoclonal Antibody
SKU:
CAB19256
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MICA (Q29983).
Cell membrane, Cytoplasm, Single-pass type I membrane protein.
Calculated MW:
43kDa
Observed MW:
43kDa/60-80kDa
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
100507436
Clone Number:
ARC2422
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MICA antibody (CAB19256) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
