The Anti-MIB1 (D1P1) Antibody (CAB3371) is a valuable tool for research involving the MIB1 protein, known for its role in regulating cell proliferation and growth. This antibody, developed by Assay Genie, is highly specific and reactive with human samples, making it ideal for use in various research applications such as immunohistochemistry and Western blotting.The MIB1 protein, also known as Mind bomb 1, is a critical regulator of Notch signaling and is involved in various cellular processes such as differentiation and development. Dysregulation of MIB1 has been linked to cancer and other diseases, making it an important target for therapeutic intervention.
With its high specificity and sensitivity, the Anti-MIB1 (D1P1) Antibody (CAB3371) enables researchers to detect and analyze MIB1 expression in different cell types and tissues, facilitating studies in cancer biology, developmental biology, and other fields. By understanding the role of MIB1 in cellular processes, researchers can gain insights that may lead to the development of novel therapies for diseases associated with MIB1 dysregulation.
Product Name:
MIB1/DIP1 Rabbit Monoclonal Antibody
SKU:
CAB3371
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MIB1/DIP1 (Q86YT6).
This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1).
Purification Method:
Affinity purification
Gene ID:
57534
Clone Number:
ARC1958
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MIB1/DIP1 Rabbit mAb (CAB3371) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
