The Anti-MGRN1 Antibody (CAB20476) is a high-quality antibody specifically designed for research involving MGRN1, a protein involved in protein degradation pathways and implicated in neurodegenerative diseases. This antibody, raised in rabbits, displays high reactivity with human samples and has been validated for use in various research applications, including Western blot and immunofluorescence.MGRN1, also known as mahogunin RING finger-1, plays a crucial role in the ubiquitin-proteasome system, which is responsible for degrading damaged or misfolded proteins within cells. Dysregulation of this system has been linked to the development of neurodegenerative disorders, making MGRN1 an important target for research in this area.
By using the Anti-MGRN1 Antibody, researchers can study the expression and localization of MGRN1 in different cell types and tissues, providing valuable insights into its function and potential implications in disease pathology. This antibody is a valuable tool for researchers in the fields of neuroscience, neurology, and protein degradation mechanisms, aiming to uncover new therapeutic targets for neurodegenerative diseases.
Product Name:
MGRN1 Rabbit Polyclonal Antibody
SKU:
CAB20476
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-538 of human MGRN1 (O60291).
Enables ubiquitin-protein transferase activity. Involved in endosome to lysosome transport; negative regulation of signal transduction; and protein monoubiquitination. Located in several cellular components, including early endosome; endoplasmic reticulum; and nucleus.
Purification Method:
Affinity purification
Gene ID:
23295
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat heart, using MGRN1 antibody (CAB20476) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
