The Anti-METAP2 Antibody (CAB3465) is a valuable tool for researchers studying METAP2, a key enzyme involved in the regulation of protein translation and cellular processes. This polyclonal antibody, developed using rabbit immunization, exhibits high specificity and sensitivity for human samples, making it ideal for Western blot analysis applications.METAP2, also known as methionine aminopeptidase 2, plays a crucial role in protein quality control and turnover by removing methionine from newly synthesized proteins. Dysregulation of METAP2 has been implicated in various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions.
By targeting the METAP2 protein, researchers can study its role in cellular processes and disease pathogenesis, leading to a better understanding of its potential as a therapeutic target. The Anti-METAP2 Antibody (CAB3465) enables precise detection and analysis of METAP2 expression in different cell types, facilitating research in molecular biology, oncology, and drug discovery.
Product Name:
METAP2 Rabbit Monoclonal Antibody
SKU:
CAB3465
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 380-478 of human METAP2 (NP_006829.1).
The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10988
Clone Number:
ARC2022
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat testis, using METAP2 Rabbit mAb (CAB3465) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
