The Anti-Mesothelin Antibody (CAB9180) is a crucial tool for researchers studying mesothelin, a cell surface glycoprotein known for its role in cancer progression and as a potential target for cancer therapy. This polyclonal antibody, produced in rabbits, shows high reactivity with mesothelin in human samples and is validated for use in various applications, including Western blotting.Mesothelin, a biomarker overexpressed in various cancers such as mesothelioma, ovarian cancer, and pancreatic cancer, has been identified as a promising target for cancer diagnosis and therapy.
Understanding the expression and function of mesothelin is essential for developing effective treatments for these aggressive cancers.By specifically binding to mesothelin, this antibody enables precise detection and analysis of the protein in different cell types, providing valuable insights for oncology research. Its versatility and reliability make it a valuable tool for investigating the role of mesothelin in cancer development and progression, as well as exploring its potential as a therapeutic target in personalized medicine approaches.
Product Name:
Mesothelin Rabbit Monoclonal Antibody
SKU:
CAB9180
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human Mesothelin (Q13421).
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
10232
Clone Number:
ARC1464
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Mesothelin Rabbit mAb (CAB9180) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
