MDM2 Rabbit Polyclonal Antibody (CAB13327)
- SKU:
- CAB13327
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | MDM2 Rabbit Polyclonal Antibody |
SKU: | CAB13327 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-430 of human MDM2 (NP_001354919.1). |
Sequence: | CVIR EICC ERSS SSES TGTP SNPD LDAG VSEH SGDW LDQD SVSD QFSV EFEV ESLD SEDY SLSE EGQE LSDE DDEV YQVT VYQA GESD TDSF EEDP EISL ADYW KCTS CNEM NPPL PSHC NRCW ALRE NWLP EDKG KDKG EISE KAKL ENST QAEE GFDV PDCK KTIV NDSR ESCV EEND DKIT QASQ SQES EDYS QPST SSSI IYSS QEDV KEFE REET QDKE ESVE SSL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | HDMX; LSKB; hdm2; ACTFS; MDM2 |
Positive Sample: | C2C12 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, nucleolus, nucleoplasm. |
Calculated MW: | 55kDa |
Observed MW: | 55kDa |
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Purification Method: | Affinity purification |
Gene ID: | 4193 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |