MDH1 Rabbit Monoclonal Antibody (CAB9673)
- SKU:
- CAB9673
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HEL-S-32
- MDH-s
- MDHA
- MGC:1375
- MOR2
- Research Area:
- Metabolism
Description
Product Name: | MDH1 Rabbit Monoclonal Antibody |
SKU: | CAB9673 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 235-334 of human MDH1 (P40925). |
Sequence: | IKAR KLSS AMSA AKAI CDHV RDIW FGTP EGEF VSMG VISD GNSY GVPD DLLY SFPV VIKN KTWK FVEG LPIN DFSR EKMD LTAK ELTE EKES AFEF LSSA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | KAR; MDHA; MOR2; DEE88; MDH-s; EIEE88; HEL-S-32; MGC:1375; MDH1 |
Positive Sample: | HeLa,Jurkat,U-251MG,Mouse liver,Mouse brain,Rat kidney,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 36kDa |
Observed MW: | 36kDa |
This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6.
Purification Method: | Affinity purification |
Gene ID: | 4190 |
Clone Number: | ARC1692 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |