The Anti-MCM2 Antibody (CAB20699) is a valuable tool for researchers studying MCM2, a protein involved in DNA replication and cell proliferation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications. By targeting the MCM2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it a crucial asset for studies in molecular biology and cancer research.MCM2, a member of the MCM protein family, is essential for the initiation and elongation phases of DNA replication. Dysregulation of MCM2 has been implicated in various diseases, including cancer, making it a promising target for therapeutic interventions.
By investigating the role of MCM2 in cellular processes, researchers can gain valuable insights into the mechanisms underlying tumorigenesis and potentially identify novel therapeutic strategies for combating cancer.Overall, the Anti-MCM2 Antibody (CAB20699) offers researchers a powerful tool for studying the function and regulation of MCM2 in a variety of biological contexts. Its high specificity and sensitivity make it an invaluable resource for advancing our understanding of DNA replication and its implications for human health and disease.
Product Name:
MCM2 Monoclonal Antibody
SKU:
CAB20699
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MCM2 (P49736).
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.
Purification Method:
Affinity purification
Gene ID:
4171
Clone Number:
ARC2596
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using MCM2 Rabbit mAb (CAB20699) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 0.3s.
