MBD2 Rabbit Monoclonal Antibody (CAB4032)
- SKU:
- CAB4032
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- DMTase
- NY-CO-41
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | MBD2 Rabbit Monoclonal Antibody |
SKU: | CAB4032 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human MBD2 (Q9UBB5). |
Sequence: | GGSG LGGD GGGC GGGG SGGG GAPR REPV PFPS GSAG PGPR GPRA TESG KRMD CPAL PPGW KKEE VIRK SGLS AGKS DVYY FSPS GKKF RSKP QLAR YLGN T |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | DMTase; NY-CO-41; MBD2 |
Positive Sample: | Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, nucleoplasm, nucleus |
Calculated MW: | 43kDa |
Observed MW: | 46kDa |
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 8932 |
Clone Number: | ARC2691 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |