The Anti-Loricrin Antibody (CAB21039) is a highly specific and sensitive antibody designed for research involving loricrin, a protein found in the skin that plays a critical role in the formation of the skin's protective barrier. This antibody, raised in rabbits, is validated for use in various applications, including immunofluorescence and immunohistochemistry.Loricrin is a key component of the skin's structure, contributing to its strength and ability to protect against environmental stressors. Research on loricrin is important for understanding skin diseases, such as ichthyosis and psoriasis, where mutations in the loricrin gene can lead to abnormalities in skin structure and function.
By using the Anti-Loricrin Antibody, researchers can study the expression and localization of loricrin in different cell types and tissues, providing valuable insights into skin biology and disease mechanisms. This antibody is a valuable tool for studies in dermatology, molecular biology, and skin health research.
Product Name:
LORICRIN Polyclonal Antibody
SKU:
CAB21039
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LORICRIN (NP_000418.2).
This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases.
Purification Method:
Affinity purification
Gene ID:
4014
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using LORICRIN antibody (CAB21039) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
