The Anti-Lipin 1 Antibody (CAB3326) is a high-quality research tool designed for the detection and analysis of Lipin 1, a key regulator of lipid metabolism and cellular signaling pathways. This polyclonal antibody, generated in rabbits, is highly specific to Lipin 1 and is validated for use in Western blot applications. By binding specifically to Lipin 1 protein, this antibody enables accurate detection and analysis in various cell types, making it an essential tool for studies in metabolic disorders, obesity, and lipid-related diseases.Lipin 1 is a critical enzyme that plays a crucial role in lipid metabolism, including triglyceride synthesis and phospholipid biosynthesis.
Dysregulation of Lipin 1 has been implicated in a variety of metabolic disorders, such as insulin resistance, fatty liver disease, and obesity. Understanding the function and regulation of Lipin 1 is essential for advancing research in these fields and developing targeted therapies for metabolic diseases.The Anti-Lipin 1 Antibody (CAB3326) provides researchers with a reliable tool to study Lipin 1 expression levels and localization in various tissues and cell types. By enabling accurate detection and analysis of Lipin 1, this antibody contributes to the advancement of research in lipid metabolism, metabolic disorders, and related diseases.
Product Name:
Lipin 1 Rabbit Monoclonal Antibody
SKU:
CAB3326
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 101-200 of human Lipin 1 (Q14693).
This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes.
Purification Method:
Affinity purification
Gene ID:
23175
Clone Number:
ARC1945
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Lipin 1 Rabbit mAb (CAB3326) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
