Legumain (LGMN) Rabbit Monoclonal Antibody (CAB6829)
- SKU:
- CAB6829
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- AEP
- LGMN1
- PRSC1
- Research Area:
- Cell Biology
Description
Product Name: | Legumain (LGMN) Rabbit Monoclonal Antibody |
SKU: | CAB6829 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-302 of human Legumain (LGMN) (Q99538). |
Sequence: | ANPR ESSY ACYY DEKR STYL GDWY SVNW MEDS DVED LTKE TLHK QYHL VKSH TNTS HVMQ YGNK TIST MKVM QFQG MKRK ASSP VPLP PVTH L |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | AEP; LGMN1; PRSC1; Legumain (LGMN) |
Positive Sample: | 293T,HepG2,MCF7,Mouse brain,Mouse spleen,Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Lysosome. |
Calculated MW: | 49kDa |
Observed MW: | 34kDa/46kDa/56kDa |
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.
Purification Method: | Affinity purification |
Gene ID: | 5641 |
Clone Number: | ARC1864 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |