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Laminin beta 1 Rabbit Monoclonal Antibody (CAB4373)

SKU:
CAB4373
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CLM
LIS5
  • Cell Biology Antibodies 17 Anti-Laminin beta 1 Antibody CAB4373
  • Cell Biology Antibodies 17 Anti-Laminin beta 1 Antibody CAB4373
$167 - $503
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Description

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Laminin beta 1 Rabbit Monoclonal Antibody (CAB4373)

The Anti-Laminin beta 1 Antibody (CAB4373) is a valuable tool for research involving laminin beta 1, a key component of the extracellular matrix that plays a crucial role in cell adhesion, migration, and signaling. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in a variety of applications, including Western blot and immunohistochemistry.Laminin beta 1 is known to be involved in a wide range of biological processes, including tissue development, wound healing, and cancer progression. By targeting this specific protein, researchers can gain insights into the mechanisms underlying these processes and identify potential therapeutic targets for diseases such as cancer and fibrosis.

The Anti-Laminin beta 1 Antibody is a powerful tool for studying the role of laminin beta 1 in various cellular contexts and can provide valuable information for advancing our understanding of tissue biology and disease progression. Its high specificity and sensitivity make it an ideal choice for researchers working in the fields of cell biology, cancer research, and regenerative medicine.

Product Name:Laminin beta 1 Rabbit Monoclonal Antibody
SKU:CAB4373
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1687-1786 of human Laminin beta 1 (P07942).
Sequence:KKTL DGEL DEKY KKVE NLIA KKTE ESAD ARRK AEML QNEA KTLL AQAN SKLQ LLKD LERK YEDN QRYL EDKA QELA RLEG EVRS LLKD ISQK VAVY STCL
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200
Synonyms:CLM; LIS5; Laminin beta 1
Positive Sample:Hep G2,Mouse heart,Rat lung
Conjugate:Unconjugated
Cellular Localization:Secreted, basement membrane, extracellular matrix, extracellular space.
Calculated MW:198kDa
Observed MW:250kDa

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.

Purification Method:Affinity purification
Gene ID:3912
Clone Number:ARC0985
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Mouse heart, using Laminin beta 1 Rabbit mAb (CAB4373) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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