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KMT2B Rabbit Polyclonal Antibody (CAB18852)

SKU:
CAB18852
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CXXC10
DYT28
HRX2
MLL1B
MLL2
MLL4
TRX2
WBP-7
WBP7
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:KMT2B Rabbit Polyclonal Antibody
SKU:CAB18852
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1370-1570 of human KMT2B (NP_055542.1).
Sequence:GLSD EDYE ILSG LPDS VLYT CGPC AGAA QPRW REAL SGAL QGGL RQVL QGLL SSKV VGPL LLCT QCGP DGKQ LHPG PCGL QAVS QRFE DGHY KSVH SFME DMVG ILMR HSEE GETP DRRA GGQM KGLL LKLL ESAF GWFD AHDP KYWR RSTR LPNG VLPN AVLP PSLD HVYA QWRQ QEPE TPES GQPP GDPS AAFQ GKDP A
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:HRX2; MLL2; MLL4; TRX2; WBP7; DYT28; MLL1B; MRD68; WBP-7; CXXC10; KMT2B
Positive Sample:A-549,F9,Rat thymus
Cellular Localization:histone methyltransferase complex, nucleoplasm, nucleus
Calculated MW:294kDa
Observed MW:320kDa

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known.

Purification Method:Affinity purification
Gene ID:9757
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates, using KMT2B antibody (CAB18852) at 1:800 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.

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