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Anti-KLF10 Antibody (CAB2433)

SKU:
CAB2433
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
EGR-alpha
EGRA
TIEG
TIEG1
Research Area:
Cell Biology
€139 - €419

Description

Anti-KLF10 Antibody (CAB2433)

The KLF10 Polyclonal Antibody (CAB2433) is a valuable tool for researchers studying KLF10, a transcription factor involved in various cellular processes, including cell growth, differentiation, and apoptosis. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in Western blot applications. By targeting the KLF10 protein, researchers can detect and analyze its expression in different cell types, making it an excellent choice for investigations in molecular biology and cancer research.KLF10, also known as TIEG1, plays a crucial role in regulating gene expression and signaling pathways that control cell fate decisions.

Its importance in cellular function makes it a promising target for studying diseases such as cancer, cardiovascular disorders, and metabolic diseases. By unravelling the molecular mechanisms involving KLF10, researchers can gain insights into potential therapeutic strategies that target these diseases at the molecular level.Overall, the KLF10 Polyclonal Antibody (CAB2433) provides researchers with a reliable tool for investigating the function and regulation of KLF10 in various physiological and pathological conditions, ultimately contributing to the advancement of scientific knowledge and the development of targeted therapies.

Product Name:KLF10 Rabbit mAb
Product Code:CAB2433
Size:20uL, 50uL, 100uL
Synonyms:EGR-alpha, EGRA, TIEG, TIEG1
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human KLF10
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, HepG2, Jurkat, Mouse lung
Immunogen:A synthesized peptide derived from human KLF10
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7071
Uniprot:Q13118
Calculated MW:53kDa
Observed MW:53kDa
UniProt Protein Function:KLF10: Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription factor; C2H2-type zinc finger protein; DNA-binding

Chromosomal Location of Human Ortholog: 8q22.2

Cellular Component: nucleus

Molecular Function:protein binding; metal ion binding; transcription factor activity

Biological Process: circadian rhythm; transcription, DNA-dependent; positive regulation of osteoclast differentiation; somatic stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; cellular response to starvation; regulation of circadian rhythm; bone mineralization; cell proliferation; negative regulation of cell proliferation; cell-cell signaling; transforming growth factor beta receptor signaling pathway; negative regulation of transcription, DNA-dependent; skeletal development

NCBI Summary:This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
UniProt Code:Q13118
NCBI GenInfo Identifier:11387050
NCBI Gene ID:7071
NCBI Accession:Q13118.1
UniProt Secondary Accession:Q13118,O75411, Q503B2, A8MVH0, B2R794, L0R4P6, L0R679
UniProt Related Accession:Q13118
Molecular Weight:480
NCBI Full Name:Krueppel-like factor 10
NCBI Synonym Full Names:Kruppel-like factor 10
NCBI Official Symbol:KLF10  
NCBI Official Synonym Symbols:EGRA; TIEG; TIEG1; EGR-alpha  
NCBI Protein Information:Krueppel-like factor 10; early growth response-alpha; zinc finger transcription factor TIEG; TGFB-inducible early growth response protein 1; transforming growth factor-beta-inducible early growth response protein 1
UniProt Protein Name:Krueppel-like factor 10
UniProt Synonym Protein Names:EGR-alpha; Transforming growth factor-beta-inducible early growth response protein 1; TGFB-inducible early growth response protein 1; TIEG-1
Protein Family:Krueppel-like factor
UniProt Gene Name:KLF10  
UniProt Entry Name:KLF10_HUMAN

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