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Anti-KIF4A Antibody (CAB9080)

SKU:
CAB9080
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
KIF4
KIF4G1
MRX100
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

Anti-KIF4A Antibody (CAB9080)

The KIF4A Polyclonal Antibody (CAB9080) is a valuable tool for researchers studying KIF4A, a protein involved in cell division and intracellular transport processes. Raised in rabbits, this antibody is highly specific to human samples and is validated for use in Western blot applications. By binding to the KIF4A protein, this antibody allows for the detection and analysis of KIF4A in various cell types, making it an essential component for studies in cell biology, cancer research, and developmental biology.

KIF4A, a member of the kinesin superfamily, plays a crucial role in mitotic spindle assembly and chromosome segregation during cell division. Dysregulation of KIF4A has been linked to various diseases, including cancer, making it an attractive target for therapeutic interventions. By understanding the function and regulation of KIF4A, researchers can uncover new insights into cell biology and potentially develop novel treatments for diseases associated with KIF4A dysfunction.

Product Name:KIF4A Rabbit mAb
Product Code:CAB9080
Size:20uL, 50uL, 100uL
Synonyms:KIF4, KIF4G1, MRX100
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human KIF4A
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, A-549
Immunogen:A synthesized peptide derived from human KIF4A
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:24137
Uniprot:O95239
Calculated MW:150kDa
Observed MW:160KDa
UniProt Protein Function:KIF4A: Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization. Belongs to the kinesin-like protein family. Chromokinesin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: Xq13.1

Cellular Component: cytoplasm; cytosol; intercellular bridge; kinesin complex; membrane; midbody; nucleoplasm; spindle microtubule

Molecular Function:microtubule motor activity; plus-end-directed microtubule motor activity; protein binding

Biological Process: anterograde axon cargo transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; cytokinesis after mitosis; microtubule-based movement; organelle organization and biogenesis; retrograde vesicle-mediated transport, Golgi to ER; spindle midzone assembly involved in mitosis

Disease: Mental Retardation, X-linked 100

NCBI Summary:This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]
UniProt Code:O95239
NCBI GenInfo Identifier:62512161
NCBI Gene ID:24137
NCBI Accession:O95239.3
UniProt Secondary Accession:O95239,Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3, B2R7V5 D3DVU4,
UniProt Related Accession:O95239
Molecular Weight:140kDa
NCBI Full Name:Chromosome-associated kinesin KIF4A
NCBI Synonym Full Names:kinesin family member 4A
NCBI Official Symbol:KIF4A  
NCBI Official Synonym Symbols:KIF4; KIF4G1; MRX100  
NCBI Protein Information:chromosome-associated kinesin KIF4A
UniProt Protein Name:Chromosome-associated kinesin KIF4A
UniProt Synonym Protein Names:Chromokinesin-A
Protein Family:Chromosome-associated kinesin
UniProt Gene Name:KIF4A  

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