The KDM3B Polyclonal Antibody (CAB2312) is a valuable tool for researchers studying the KDM3B protein, a member of the Jumonji domain-containing histone demethylase family. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.KDM3B plays a key role in epigenetic regulation by removing methyl groups from histone proteins, thereby influencing gene expression and chromatin remodeling. Its involvement in processes such as cell proliferation, differentiation, and DNA damage response makes it a relevant target for studies in cancer research and developmental biology.
By detecting and analyzing KDM3B expression in various cell types, researchers can gain insights into its function and potential implications in disease progression. The KDM3B Polyclonal Antibody is a reliable tool for investigating the mechanisms underlying epigenetic regulation and exploring therapeutic targets for conditions such as cancer and genetic disorders.
Product Name:
KDM3B Rabbit pAb
Product Code:
CAB2312
Size:
20uL, 50uL, 100uL
Synonyms:
KDM3B, 5qNCA, C5orf7, JMJD1B, NET22
Applications:
WB, IHC
Reactivity:
Human
Host Species:
Rabbit
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1059-1283 of human KDM3B (NP_057688.2).
Applications:
WB, IHC
Recommended Dilutions:
WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:
Human
Positive Samples:
HeLa
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1059-1283 of human KDM3B (NP_057688.2).
Purification Method:
Affinity purification
Storage:
Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
JMJD1B: a ubiquitous protein demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. Three alternatively spliced isoforms have been reported. Protein type: EC 1.14.11.-; Oxidoreductase; Demethylase Chromosomal Location of Human Ortholog: 5q31 Cellular Component: nucleoplasm Molecular Function: dioxygenase activity; metal ion binding Biological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin modification
