The KCNC1 Polyclonal Antibody (CAB2995) is a valuable tool for researchers studying the KCNC1 protein, a voltage-gated potassium channel subunit known for its role in regulating neuronal excitability. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications.KCNC1 is essential for modulating neuronal firing patterns and synaptic transmission in the brain, making it a key player in neurological disorders such as epilepsy and ataxia. By targeting KCNC1, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic approaches.
With its ability to specifically bind to the KCNC1 protein, the CAB2995 antibody facilitates the detection and analysis of KCNC1 expression in various cell types, making it a versatile tool for studies in neuroscience and neurology. By understanding the function of KCNC1, researchers can advance our knowledge of brain function and contribute to the development of targeted treatments for neurological diseases.
Product Name:
KCNC1 Rabbit Polyclonal Antibody
SKU:
CAB2995
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNC1 (NP_004967.1).
This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563).
Purification Method:
Affinity purification
Gene ID:
3746
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat liver, using KCNC1 Rabbit pAb (CAB2995) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
