Kaiso/ZBTB33 Rabbit Monoclonal Antibody (CAB3770)
- SKU:
- CAB3770
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ZNF-kaiso
- ZNF348
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | Kaiso/ZBTB33 Rabbit Monoclonal Antibody |
SKU: | CAB3770 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 573-672 of human Kaiso/ZBTB33 (Q86T24). |
Sequence: | HSQD PSGD SKLY RLHP CRSL QIRQ YAYL SDRS STIP AMKD DGIG YKVD TGKE PPVG TTTS TQNK PMTW EDIF IQQE NDSI FKQN VTDG STEF EFII PESY |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | ZNF348; ZNF-kaiso; Kaiso/ZBTB33 |
Positive Sample: | A-549,SH-SY5Y,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, nucleolus, nucleoplasm, nucleus, plasma membrane |
Calculated MW: | 74KDa |
Observed MW: | 80kDa |
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
Purification Method: | Affinity purification |
Gene ID: | 10009 |
Clone Number: | ARC2086 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |