The JMJD1C Polyclonal Antibody (CAB20153) is a valuable tool for researchers studying JMJD1C, a histone demethylase involved in the regulation of gene expression and chromatin remodeling. This antibody, produced in rabbits, has high specificity for JMJD1C in human samples and has been validated for use in Western blotting and immunohistochemistry.JMJD1C is known to play a key role in various biological processes, including cell differentiation, metabolism, and development.
Dysregulation of JMJD1C has been linked to diseases such as cancer, diabetes, and neurological disorders, making it a promising target for therapeutic interventions. By using the JMJD1C Polyclonal Antibody, researchers can effectively detect and analyze JMJD1C expression in different cell types, advancing our understanding of its functional significance in health and disease.
Product Name:
JMJD1C Rabbit Polyclonal Antibody
SKU:
CAB20153
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 354-448 of human JMJD1C (NP_116165.1).
The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
221037
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using JMJD1C Rabbit pAb (CAB20153) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
