The Anti-JAM-A Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0236) is a highly specific antibody designed for research involving JAM-A, a cell adhesion molecule known to play a crucial role in cell-cell interactions. This rabbit monoclonal antibody is engineered with chimeric recombinant technology for enhanced binding affinity and specificity.JAM-A, also known as Junctional Adhesion Molecule A, is involved in various physiological processes, including cell migration, proliferation, and differentiation. Its expression has been implicated in cancer progression, inflammation, and immune responses. This antibody is well-suited for applications such as immunofluorescence, immunohistochemistry, and flow cytometry, enabling researchers to accurately detect and analyze JAM-A in different cell types and tissues.
The Anti-JAM-A Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0236) offers researchers a reliable tool for studying the role of JAM-A in various biological processes and diseases. With its high specificity and sensitivity, this antibody is a valuable asset for investigations in cancer biology, immunology, and vascular physiology. By targeting JAM-A, researchers can gain insights into its functional significance and potential therapeutic applications in related pathologies.
SKU:
HDAB0236
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC278
Synonyms:
CD321, JAM,JAM1, JAMA, JCAM, KAT, PAM-1
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
