The Anti-JAK1 Antibody (CAB11963) is a crucial tool for researchers studying the JAK1 protein, a key player in the JAK/STAT signaling pathway involved in cell growth, differentiation, and immune response regulation. This polyclonal antibody, developed using advanced technology, exhibits high specificity and sensitivity for human samples, making it an ideal choice for Western blot applications.The JAK1 protein is essential for the activation of various cytokine receptors and subsequent signaling cascades, making it a critical target for understanding immune responses, inflammatory processes, and cell proliferation.
By targeting JAK1 with this antibody, researchers can study its expression, localization, and function in different cell types, providing valuable insights into its role in diseases such as cancer, autoimmune disorders, and inflammatory conditions.With its validated performance and broad applicability in immunology and cancer research, the Anti-JAK1 Antibody (CAB11963) enables precise detection and analysis of JAK1 protein levels, making it an invaluable tool for studying the mechanisms underlying various diseases and developing targeted therapies.
Product Name:
JAK1 Rabbit Monoclonal Antibody
SKU:
CAB11963
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human JAK1 (P23458).
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3716
Clone Number:
ARC0434
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse lung , using JAK1 Rabbit mAb (CAB11963) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
