JAK1 Rabbit Monoclonal Antibody (CAB11963)
- SKU:
- CAB11963
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- JAK1A
- JAK1B
- JTK3
- Research Area:
- Cell Biology
Description
| Product Name: | JAK1 Rabbit Monoclonal Antibody |
| SKU: | CAB11963 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human,Mouse,Rat |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 600-700 of human JAK1 (P23458). |
| Sequence: | GTLM DYKD DEGT SEEK KIKV ILKV LDPS HRDI SLAF FEAA SMMR QVSH KHIV YLYG VCVR DVEN IMVE EFVE GGPL DLFM HRKS DVLT TPWK FKVA KQLA S |
| Tested Applications: | WB IHC-P ELISA |
| Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
| Synonyms: | JTK3; AIIDE; JAK1A; JAK1B; JAK1 |
| Positive Sample: | Mouse lung |
| Conjugate: | Unconjugated |
| Cellular Localization: | cytoplasm, cytoskeleton, cytosol, endosome, focal adhesion, nucleus |
| Calculated MW: | 133kDa |
| Observed MW: | 130kDa |
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants.
| Purification Method: | Affinity purification |
| Gene ID: | 3716 |
| Clone Number: | ARC0434 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |
 | Western blot analysis of lysates from Mouse lung , using JAK1 Rabbit mAb (CAB11963) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s. |
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