The Anti-ITPR2 Antibody (CAB19320) is a valuable tool for researchers interested in studying ITPR2, a protein involved in calcium signaling and regulation. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to the ITPR2 protein, enabling precise detection and analysis in various cell types.ITPR2, also known as inositol 1,4,5-trisphosphate receptor type 2, plays a crucial role in intracellular calcium release and signaling pathways. Dysregulation of ITPR2 has been implicated in various diseases, including neurodegenerative disorders and cancers.
By targeting ITPR2, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.With its specificity and accuracy in detecting ITPR2, the Anti-ITPR2 Antibody (CAB19320) is an essential tool for advancing research in the fields of neuroscience, oncology, and cell biology. By elucidating the role of ITPR2 in cellular function and disease progression, this antibody contributes to the development of novel treatment strategies and the advancement of biomedical science.
Product Name:
ITPR2 Rabbit Polyclonal Antibody
SKU:
CAB19320
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2415-2480 of human ITPR2 (NP_002214.2).
Sequence:
LFLK DDFT MEVD RLKN RTPV TGSH QVPT MTLT TMME ACAK ENCS PTIP ASNT ADEE YEDG IERT CD
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.
Purification Method:
Affinity purification
Gene ID:
3709
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat lung using ITPR2 Rabbit pAb (CAB19320) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
