ITPR2 Rabbit Polyclonal Antibody (CAB19320)
- SKU:
- CAB19320
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ANHD
- CFAP48
- INSP3R2
- IP3R2
- ITPR2
Description
Product Name: | ITPR2 Rabbit Polyclonal Antibody |
SKU: | CAB19320 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2415-2480 of human ITPR2 (NP_002214.2). |
Sequence: | LFLK DDFT MEVD RLKN RTPV TGSH QVPT MTLT TMME ACAK ENCS PTIP ASNT ADEE YEDG IERT CD |
Tested Applications: | IHC-P IF/ICC ELISA |
Recommended Dilution: | IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | ANHD; IP3R2; CFAP48; INSP3R2; ITPR2 |
Conjugate: | Unconjugated |
Cellular Localization: | cell cortex, endoplasmic reticulum, nucleoplasm, plasma membrane |
Calculated MW: | 308kDa |
Observed MW: | Refer to figures |
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.
Purification Method: | Affinity purification |
Gene ID: | 3709 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |