The Anti-Itch KO Validated Antibody (CAB8624) is a specialized antibody designed for research involving anti-itch mechanisms and pathways. This antibody, validated for Knockout (KO) studies, is highly specific and sensitive for detecting anti-itch molecules in various cell types. It is raised in rabbits and is proven to be effective in Western blot applications for analyzing the expression levels of anti-itch proteins.The anti-itch antibody targets key molecules involved in itch sensation and signaling pathways, providing a valuable tool for studying the mechanisms underlying itch perception and potential therapeutic targets for treating itch-related disorders such as eczema, psoriasis, and allergic reactions.
Understanding the role of anti-itch molecules can lead to the development of targeted therapies that provide relief for patients suffering from chronic itch conditions.Overall, the Anti-Itch KO Validated Antibody (CAB8624) is an essential tool for researchers in the fields of dermatology, immunology, and neurobiology who are investigating the molecular mechanisms of itch and developing new treatment strategies for itch-related disorders.
Product Name:
[KO Validated] ITCH Rabbit Monoclonal Antibody
SKU:
CAB8624
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ITCH (Q96J02).
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
83737
Clone Number:
ARC1759
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ITCH Rabbit mAb (CAB8624) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
