The Anti-IRAK4 Antibody (CAB20839) is a valuable tool for researchers studying the IRAK4 protein, a key player in the innate immune signaling pathway. This polyclonal antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting IRAK4 in human samples. It has been validated for use in Western blot applications, enabling researchers to analyze IRAK4 expression levels in various cell types and tissues.IRAK4, or interleukin-1 receptor-associated kinase 4, is essential for initiating immune responses to pathogens and plays a crucial role in inflammatory processes.
Dysregulation of IRAK4 signaling has been implicated in various diseases, including autoimmune disorders, inflammatory conditions, and cancer. By targeting IRAK4, researchers can gain insights into the mechanisms underlying these diseases and develop novel therapeutic strategies.The Anti-IRAK4 Antibody is a valuable tool for investigating the function of IRAK4 and its role in disease pathogenesis. With its high reactivity and specificity, this antibody enables precise detection and analysis of IRAK4, making it an essential reagent for immunology and cancer research studies.
Product Name:
IRAK4 Monoclonal Antibody
SKU:
CAB20839
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human IRAK4 (NP_057207.2).
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
51135
Clone Number:
ARC51289
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type(WT) and IRAK4 knockdown (KD) 293T cells, using [KD Validated] IRAK4 Rabbit mAb (CAB20839) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
