The Anti-Involucrin Antibody (CAB13311) is a highly specific research tool designed for the detection of involucrin, a marker of epidermal differentiation and cornification. This antibody, produced in rabbits, is ideal for use in immunohistochemistry and immunofluorescence applications, allowing for the visualization and analysis of involucrin expression in various tissue samples.Involucrin is a key protein involved in the terminal differentiation of keratinocytes, forming cross-linked structures that contribute to the structural integrity of the skin barrier. Its expression is essential for the formation of the cornified envelope, a protective layer that prevents water loss and protects against external insults.
Research into involucrin expression and regulation is important for understanding skin development, wound healing, and skin diseases such as psoriasis and atopic dermatitis.The Anti-Involucrin Antibody (CAB13311) provides researchers with a valuable tool for studying the role of involucrin in skin biology and disease pathology. Its high specificity and sensitivity make it a reliable choice for investigating involucrin expression patterns and cellular localization in both normal and diseased skin tissues. This antibody is a vital asset for studies focused on skin biology, dermatology, and the development of new therapeutic approaches for skin disorders.
Product Name:
Involucrin Rabbit Monoclonal Antibody
SKU:
CAB13311
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Involucrin (P07476).
centrosome, cytoplasm, cytosol, extracellular exosome, nuclear body
Calculated MW:
68kDa
Observed MW:
90kDa
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.
Purification Method:
Affinity purification
Gene ID:
3713
Clone Number:
ARC1802
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung, using Involucrin Rabbit mAb (CAB13311) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
