The INTS8 Polyclonal Antibody (CAB20513) is a valuable tool for researchers studying the INTS8 protein, a key component of the Integrator complex involved in RNA processing and transcription regulation. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in Western blot and immunofluorescence applications. By binding to INTS8, the antibody allows for the visualization and analysis of this protein in various cell types, making it particularly useful for studies in molecular biology and gene expression regulation.INTS8 is essential for the proper functioning of the Integrator complex, which plays a crucial role in processing non-coding RNAs and regulating gene expression.
Dysregulation of INTS8 has been linked to various diseases, including cancer, neurological disorders, and developmental abnormalities. Investigating the role of INTS8 in these conditions can provide valuable insights into disease mechanisms and potential therapeutic targets. The INTS8 Polyclonal Antibody is a reliable tool for researchers seeking to further understand the functions of INTS8 and its implications in human health and disease.
Product Name:
INTS8 Rabbit Polyclonal Antibody
SKU:
CAB20513
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 600-800 of human INTS8 (NP_060334.2).
This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
55656
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse brain, using INTS8 antibody (CAB20513) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
