The INTS6 Polyclonal Antibody (CAB20602) is a valuable tool for research involving INTS6, a critical component of the Integrator complex that plays a crucial role in transcription regulation. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding to the INTS6 protein, this antibody allows for the detection and analysis of INTS6 in various cell types, making it an ideal choice for studies in molecular biology, gene regulation, and epigenetics.
INTS6 is essential for proper transcriptional regulation and has been implicated in a variety of cellular processes, including RNA splicing and mRNA processing. Understanding the function of INTS6 is key to unraveling its role in gene expression and its potential involvement in diseases such as cancer, neurological disorders, and developmental abnormalities. By targeting INTS6, researchers can gain valuable insights into gene regulation mechanisms and potentially uncover new therapeutic targets for these conditions.
Product Name:
INTS6 Polyclonal Antibody
SKU:
CAB20602
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 700-887 of human INTS6 (NP_036273.1).
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
26512
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using INTS6 Rabbit pAb (CAB20602) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
