Insulin Rabbit Polyclonal Antibody (CAB2090)
- SKU:
- CAB2090
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Plant
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
Product Name: | Insulin Rabbit Polyclonal Antibody |
SKU: | CAB2090 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human INS (NP_000198.1). |
Sequence: | MALW MRLL PLLA LLAL WGPD PAAA FVNQ HLCG SHLV EALY LVCG ERGF FYTP KTRR EAED LQVG QVEL GGGP GAGS LQPL ALEG SLQK RGIV EQCC TSIC SLYQ LENY CN |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | IDDM; ILPR; IRDN; IDDM1; IDDM2; PNDM4; MODY10; Insulin |
Positive Sample: | Moouse pancreas,Rat pancreas |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 12kDa |
This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
Purification Method: | Affinity purification |
Gene ID: | 3630 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |