The Anti-IL4RA Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0242) is a valuable tool for researchers studying the IL4RA protein, which plays a vital role in immune modulation and allergic responses. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting.IL4RA, also known as interleukin-4 receptor subunit alpha, is involved in signaling pathways that regulate immune responses, making it a key target for studies in immunology and cancer research.
By binding to the IL4RA protein, this antibody enables precise detection and analysis in different cell types, offering insights into the mechanisms underlying immune regulation and disease development.Research into IL4RA is essential for understanding its role in diseases such as cancer, asthma, and autoimmune disorders, where immune dysregulation is a hallmark. By elucidating the function of IL4RA, researchers can uncover potential therapeutic targets and strategies for modulating immune responses in various pathological conditions.
SKU:
HDAB0242
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC284
Synonyms:
CD124, IL-4RA, IL4RA
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
