The Anti-IL21R Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0215) is a powerful tool for researchers studying the interleukin-21 receptor (IL21R), a key player in immune regulation and cell signaling. This antibody, developed using cutting-edge technology, offers high specificity and sensitivity for detecting IL21R in human samples.IL21R is a crucial component of the immune system, involved in modulating immune responses and inflammation. Dysregulation of IL21R signaling has been implicated in various diseases, including autoimmune disorders, inflammatory conditions, and certain types of cancer. By targeting IL21R, researchers can gain valuable insights into disease mechanisms and potentially develop novel therapeutic strategies.
With its chimeric recombinant rabbit monoclonal structure, the HDAB0215 antibody provides superior performance in a variety of applications, such as Western blotting, immunohistochemistry, and flow cytometry. Its versatility and reliability make it an essential tool for studies in immunology, oncology, and beyond.Overall, the Anti-IL21R Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0215) offers researchers a reliable and accurate means to investigate the role of IL21R in health and disease, paving the way for advancements in therapeutic interventions and personalized medicine.
SKU:
HDAB0215
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC225
Synonyms:
CD360, IMD56, NILR
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
