Anti-IL1B Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0229)
- SKU:
- HDAB0229
- Product Type:
- Rabbit Monoclonal Antibody
- Antibody Type:
- Monoclonal Antibody
- Size:
- 100 μg
- Reactivity:
- Human
- Host Species:
- Rabbit
- Antibody Isotype:
- Rabbit/Human Fc chimeric IgG1
- Clone:
- DMC271
- Synonyms:
- IL-1, IL1-BETA, IL1F2
Frequently bought together:
Description
system_update_altDatasheet
SKU: | HDAB0229 |
Size: | 100 µg |
Clonality: | Monoclonal |
Clone: | DMC271 |
Synonyms: | IL-1, IL1-BETA, IL1F2 |
Applications: | Flow Cyt |
Recommended Dilution: | Flow Cyt 1:100 |
Host Species: | Rabbit |
Isotype: | Rabbit/Human Fc chimeric IgG1 |
Reactivity: | Human |
Purification Method: | Purified from cell culture supernatant by affinity chromatography |
Formulation: | Powder |
Buffer: | 1XPBS |
Storage: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature. |
Usage: | Research use only |
Background: | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. |