The Anti-IL1B Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0229) is a highly specific and sensitive tool for researchers studying IL1B, a key cytokine involved in inflammation and immune responses. This antibody, developed using advanced chimeric recombinant technology, offers superior binding affinity and specificity compared to traditional monoclonal antibodies.IL1B, also known as interleukin-1 beta, is a potent pro-inflammatory cytokine that plays a central role in the regulation of immune responses and inflammation. Dysregulation of IL1B signaling has been implicated in a variety of inflammatory disorders, making it an attractive target for therapeutic intervention.The Anti-IL1B Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0229) is ideal for use in various research applications, including Western blotting, immunohistochemistry, and flow cytometry.
Its high sensitivity and specificity ensure accurate and reliable detection of IL1B in samples from various sources, enabling researchers to study the role of this cytokine in inflammatory diseases, cancer, and other immune-related conditions.Overall, the Anti-IL1B Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0229) is a valuable tool for researchers interested in exploring the significance of IL1B in immune regulation and inflammation, offering precise and reliable results for a wide range of research purposes.
SKU:
HDAB0229
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC271
Synonyms:
IL-1, IL1-BETA, IL1F2
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
