The Anti-IL15RA Recombinant Rabbit Monoclonal Antibody (HDAB0197) is a powerful tool for researchers studying the IL15RA protein, a receptor involved in immune function and inflammation. This antibody, generated in rabbit cells, exhibits high specificity and sensitivity for detecting IL15RA in human samples, making it an invaluable asset for studies in immunology and cancer research.IL15RA is a key player in immune regulation, particularly in the activation and proliferation of T lymphocytes and natural killer cells. Its dysregulation has been linked to various diseases, including cancer, autoimmune disorders, and inflammatory conditions. By targeting IL15RA with this antibody, researchers can gain valuable insights into the role of this receptor in disease pathogenesis and potentially identify new therapeutic targets for intervention.
With its ability to specifically bind to IL15RA, the Anti-IL15RA Recombinant Rabbit Monoclonal Antibody (HDAB0197) offers researchers a precise tool for investigating the function and expression of this important receptor in diverse cell types and experimental settings. Its reliability and reproducibility in Western blot applications make it an essential reagent for advancing our understanding of immune responses and developing novel treatment strategies for immune-related disorders.
SKU:
HDAB0197
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM206
Synonyms:
CD215
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.
