The Anti-IL15RA Antibody (CAB2983) is a high-quality polyclonal antibody designed for researchers studying IL15RA, a receptor protein involved in immune responses. This antibody, developed using rabbit immunization techniques, has been specifically validated for use in Western blot applications and is highly reactive with human samples.IL15RA plays a crucial role in immune regulation, particularly in promoting the activation and survival of immune cells. By targeting IL15RA, researchers can gain valuable insights into the mechanisms underlying immune response modulation and its implications in diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
With its ability to bind to the IL15RA protein and facilitate its detection and analysis in various cell types, the Anti-IL15RA Antibody (CAB2983) is an essential tool for studies in immunology and cancer research. By understanding the functions and interactions of IL15RA, researchers can pave the way for the development of novel therapeutic approaches aimed at harnessing or modulating immune function for improved clinical outcomes.
Product Name:
IL15RA Rabbit Polyclonal Antibody
SKU:
CAB2983
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 167-267 of human CD215/IL-15R alpha (NP_002180.1).
Sequence:
SHES SHGT PSQT TAKN WELT ASAS HQPP GVYP QGHS DTTV AIST STVL LCGL SAVS LLAC YLKS RQTP PLAS VEME AMEA LPVT WGTS SRDE DLEN CSHH L
Tested Applications:
WBIF/ICCELISA
Recommended Dilution:
WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200
Synonyms:
CD215; CD215/IL-15R alpha
Positive Sample:
THP-1
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasmic vesicle membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane, Membrane, Nucleus membrane, Secreted, Single-pass type I membrane protein, Single-pass type I membrane protein, extracellular space.
Calculated MW:
28kDa
Observed MW:
60kDa
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.
Purification Method:
Affinity purification
Gene ID:
3601
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of THP-1 cells, using CD215/IL-15R alpha antibody (CAB2983) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
