IL15RA Rabbit Polyclonal Antibody (CAB2983)
- SKU:
- CAB2983
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- IL15RA
- CD215
- Research Area:
- Cell Biology
Description
Product Name: | IL15RA Rabbit Polyclonal Antibody |
SKU: | CAB2983 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 167-267 of human CD215/IL-15R alpha (NP_002180.1). |
Sequence: | SHES SHGT PSQT TAKN WELT ASAS HQPP GVYP QGHS DTTV AIST STVL LCGL SAVS LLAC YLKS RQTP PLAS VEME AMEA LPVT WGTS SRDE DLEN CSHH L |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | CD215; CD215/IL-15R alpha |
Positive Sample: | THP-1 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasmic vesicle membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane, Membrane, Nucleus membrane, Secreted, Single-pass type I membrane protein, Single-pass type I membrane protein, extracellular space. |
Calculated MW: | 28kDa |
Observed MW: | 60kDa |
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.
Purification Method: | Affinity purification |
Gene ID: | 3601 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |