The Anti-IL10 Antibody (CAB12255) is a cutting-edge research tool designed for studying IL10, a key cytokine with diverse immunoregulatory functions. This polyclonal antibody, produced in rabbits, demonstrates high specificity and sensitivity for detecting IL10 in human samples, making it an invaluable tool for researchers working in immunology and inflammation studies.IL10 is a crucial anti-inflammatory cytokine that plays a vital role in regulating immune responses and maintaining immune homeostasis. Dysregulation of IL10 has been implicated in various autoimmune diseases, inflammatory disorders, and even cancer progression. By targeting IL10 with this antibody, researchers can gain deeper insights into the molecular mechanisms underlying these diseases and potentially identify new therapeutic targets.
With its ability to detect IL10 in Western blot applications, this antibody provides a versatile tool for investigating the role of IL10 in different cell types and disease contexts. By studying IL10 dynamics and signaling pathways, researchers can pave the way for developing novel strategies for modulating immune responses and treating inflammatory conditions. Take your research to the next level with the Anti-IL10 Antibody and unravel the complexities of immune regulation.
Product Name:
IL10 Rabbit Monoclonal Antibody
SKU:
CAB12255
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IL10 (P22301).
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Purification Method:
Affinity purification
Gene ID:
3586
Clone Number:
ARC0650
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using IL10 Rabbit mAb (CAB12255) at 1:1000 dilution.THP-1 cells were treated by LPS and Brefeldin A for different times of stimulation.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
